MCAT Biology

A comprehensive introduction to key biological concepts tested on the MCAT, focusing on cellular processes, genetics, and the integration of biological systems.

Advanced Topics

Gene Regulation and Epigenetics

Turning Genes On and Off

Not all genes are active all the time. Cells use gene regulation to control which genes are expressed, and when. This allows for specialization—like muscle cells vs. nerve cells—even though all cells have the same DNA!

Mechanisms of Gene Regulation

  • Transcription factors: Proteins that turn genes on or off.
  • Enhancers and silencers: DNA regions that increase or decrease gene expression.
  • Epigenetic modifications: Chemical changes (like DNA methylation) that affect gene activity without changing the DNA sequence.

Epigenetics in Action

Epigenetics explains why identical twins can look and act differently, and why environmental factors (like diet or stress) can affect gene expression.

Medical Importance

Epigenetic changes can play roles in cancer, mental illness, and inheritance patterns not explained by DNA sequence alone.

Examples

  • Cancer cells often have abnormal DNA methylation, turning off genes that control cell growth.

  • Childhood nutrition can lead to lasting epigenetic changes affecting health in adulthood.

In a Nutshell

Gene regulation and epigenetics let cells fine-tune gene activity, shaping development and health.

Key Terms

Epigenetics
Heritable changes in gene expression not caused by changes in DNA sequence.
Transcription Factor
A protein that regulates the transcription of specific genes.