MCAT Biology

A comprehensive introduction to key biological concepts tested on the MCAT, focusing on cellular processes, genetics, and the integration of biological systems.

Basic Concepts

Cellular Metabolism and Energy

Life's Chemistry Set

Cells need energy to survive, and they use intricate chemical pathways to get it. Together, these pathways are called metabolism.

ATP: The Energy Currency

The primary energy molecule used by cells is adenosine triphosphate (ATP). Cells generate ATP through:

  • Glycolysis: Breaks down glucose into pyruvate, yielding a small amount of ATP.
  • Citric Acid Cycle (Krebs Cycle): Produces high-energy molecules (NADH, FADH₂) for the next step.
  • Electron Transport Chain (ETC): Uses electrons from NADH and FADH₂ to generate lots of ATP.

The overall equation for cellular respiration: \[ \text{C}6\text{H}{12}\text{O}_6 + 6\ \text{O}_2 \rightarrow 6\ \text{CO}_2 + 6\ \text{H}_2\text{O} + \text{Energy} (ATP) \]

Metabolism in Action

When you eat, carbohydrates, fats, and proteins are broken down and converted into ATP, powering everything you do—from thinking to running!

Cellular Respiration vs. Fermentation

  • Aerobic respiration: Requires oxygen, produces lots of ATP.
  • Anaerobic fermentation: Occurs without oxygen, yields less ATP but is essential in low-oxygen situations (like sprinting).

Examples

  • Muscle cramps during intense exercise occur because your cells switch to anaerobic fermentation, making less ATP and producing lactic acid.

  • Mitochondrial diseases can lead to fatigue because cells can’t generate enough ATP.

In a Nutshell

Metabolism describes how cells extract, store, and use energy to power life.

Key Terms

ATP
Adenosine triphosphate, the main energy carrier in cells.
Glycolysis
The first step in cellular respiration, breaking down glucose for energy.