Inhibitors

Practice Questions

Physical Chemistry › Inhibitors

Questions
6
1

The slope of a Lineweaver-Burk plot is and the x-intercept is . Upon addition of a noncompetitive inhibitor the slope increases to . Which of the following is the correct value of (Michaelis constant) after the addition of the inhibitor?

2

Upon addition of an inhibitor, which of the following is expected to happen in a catalytic reaction?

3

A researcher is analyzing the effects of an unknown inhibitor. He observes that the inhibition can be overcome by increasing the concentration of the substrate. What can you conclude about this inhibitor?

4

__________ inhibitors bind to the active site and __________ inhibitors alter the binding affinity of substrate and catalyst.

5

Which of the following is true regarding competitive inhibition?

I. They form covalent bonds with the active site

II. They are reversible

III. They are similar to allosteric inhibitors

6

Which of the following is true regarding noncompetitive inhibitors?

I. They do not form covalent bonds with the active site

II. They alter both Km and Vmax

III. They alter the shape of the active site

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