Glia

Practice Questions

MCAT Biology › Glia

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1

Which of the following describes the difference between oligodendrocytes and Schwann cells?

2

Which of the following glial cells produces cerebrospinal fluid?

3

What is the major difference between Schwann cells and oligodendrocytes?

4

The cells that form myelin sheaths around axons outside of the central nervous system are __________.

5

In humans, nerve impulses are transmitted with the coordinated action of sodium and potassium ion channels. These channels open in a specific sequence, to allow for membrane potential changes to take place in a directional manner along the length of an axon.

Figure 1 depicts a single phospholipid layer of a cell membrane, and three transmembrane channels important to action potential propagation.

Untitled

Action potential propagation down a membrane, as depicted in the figure, is typically very slow. Which of the following cell types is responsible for speeding nerve propagation by insulating peripheral axons?

6

Excessive stimulation of the ulnar nerve results in the sensation known as the "funny bone," and can cause discomfort in the elbow and forearm. What cells are responsible for the myelination of the ulnar nerve?

7

Prions are the suspected cause of a wide variety of neurodegenerative diseases in mammals. According to prevailing theory, prions are infectious particles made only of protein and found in high concentrations in the brains of infected animals. All mammals produce normal prion protein, PrPC, a transmembrane protein whose function remains unclear.

Infectious prions, PrPRes, induce conformational changes in the existing PrPC proteins according to the following reaction:

PrPC + PrPRes → PrPRes + PrPRes

The PrPRes is then suspected to accumulate in the nervous tissue of infected patients and cause disease. This model of transmission generates replicated proteins, but does so bypassing the standard model of the central dogma of molecular biology. Transcription and translation apparently do not play a role in this replication process.

This theory is a major departure from previously established biological dogma. A scientist decides to test the protein-only theory of prion propagation. He establishes his experiment as follows:

Homogenized brain matter of infected rabbits is injected into the brains of healthy rabbits, as per the following table:

Rabbit 1 and 2: injected with normal saline on days 1 and 2

The above trials serve as controls.

Rabbit 3 and 4: injected with homogenized brain matter on days 1 and 2

The above trials use unmodified brain matter.

Rabbit 5 and 6: injected with irradiated homogenized brain matter on days 1 and 2

The above trials use brain matter that has been irradiated to destroy nucleic acids in the homogenate.

Rabbit 7 and 8: injected with protein-free centrifuged homogenized brain matter on days 1 and 2

The above trials use brain matter that has been centrifuged to generate a protein-free homogenate and a protein-rich homogenate based on molecular weight.

Rabbit 9 and 10: injected with boiled homogenized brain matter on days 1 and 2

The above trials use brain matter that have been boiled to destroy any bacterial contaminants in the homogenate.

A scientist shows that PrPC in normal nervous cells helps speed nervous transmission. What other structures help speed nervous transmission?

8

Diseases which destroy the myelin sheath of neurons cause __________.

9

Which of the following structures creates a myelin sheath for axons in the central nervous system?

10

Where might one find Schwann cells?

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