The early developmental stress Jeanie experienced caused the neural connections in her hippocampus to stunt growth, resulting in a smaller than average hippocampus. Antidepressants are ineffective initially because Jeanie's brain needs more neurogenisis in her hippocampus to assist with her mood.

Jeanie's brain is not receptive to the type of neurotransmitter being delivered by the anti-depressant. Jeanie needs an anti-depressant that delivers a different combination of neurotransmitters than the ones she has already tried.

The early childhood stress Jeanie experienced caused her limbic system to rewire it's route through her brain. Therefore, the anti-depressants are effecting a part of her brain that she does not currently have access to and becoming ineffective.

Jeanie's brain is overproducing the neurotransmitters that the anti-depressant is delivering. Instead of decreasing Jeanie's depression, it is intensifying it by producing more of what she already has.

None of these

Schizophrenia

Bipolar Disorder

Parkinson's Disorder

Psychosis

Tourette's Syndrom