Botulinum toxin is a neurotoxin that causes paralysis of the muscles. This is accomplished by cleavage of SNARE proteins contained within the presynaptic compartment of the neuron. Given this information, which of the following best describes how botulinum toxin causes paralysis?

Which of the following motor proteins carries vesicular cargo along microtubules exclusively towards the microtubule organizing center (MTOC)?

Which of the following proteins/structures are involved in the mechanism of vesicular transport?

I. Actin microfilament cytoskeleton

II. Intermediate filament cytoskeleton

III. Kinesin

IV. Microtubule cytoskeleton

Which of the following portions of the cytoskeleton are used extensively for vesicular transport?

I. Actin

II. Intermediate filaments

III. Microtubules

SNARE (soluble NSF attachment protein receptor) proteins are crucial molecular mediators of vesicular exocytosis. SNAREs require calcium to mediate exocytosis; namely, one protein component of the SNARE complex interacts with synaptotagmin in a calcium dependent fashion. Which of the following answers lists the SNARE proteins that interacts with synaptotagmin?

Which of the following protein coats would most likely be seen on a vesicle directed towards the plasma membrane?