They allow the release of cytochrome c from the mitochondria into the cytosol, which activates procaspase

They bind and block Bcl2 from inhibiting Bax and Bak activators

They are a major component of the apoptosome

They cleave procaspase into caspase, which initiates the caspase cascade

GEFs 'activate' small GTPases and GAPs 'deactivate' small GTPases.

GEFs 'deactivate' small GTPases and GAPs 'activate' small GTPases.

GEFs add guanine nucleotides to small GTPases and GAPs cleave them to promote activation.

GEFs and GAPs have no functional difference, only slight differences in structure.

GEFs are cytosolic and act on proteins there, while GAPs are nuclear and act on proteins within the nucleus.

and

and

Protein kinase C (PKC) and

and protein kinase C (PKC)

Protein kinase C (PKC) and

The amino acid sequence

The protein's interactions with other polypeptides

Specific hydrogen bonds

The proteins peptide bonds

The proteins interactions with chaperone proteins