GRE Subject Test: Biochemistry, Cell, and Molecular Biology › Help with Nuclear Transport
Which of the following choices would have the biggest effect on nuclear transport?
A mutated, non-functional copy of RanGAP
An inhibitor that globally targets importins at their cargo binding sites
An inhibitor that globally targets exportins at their cargo binding sites
A non-functional copy of the gene that encodes CRM1
What is the function of RanGAP in relation to nuclear import and export?
Maintain a gradient of GTP/GDP bound Ran
Bind cargo proteins
Bind importins/exportins and bring them through the nuclear pore complex
Attach GTP to Ran