Promote formation of euchromatin and increase gene expression

Facilitate phosphorylation of these lysines by kinases

Signal for ubiquitin-mediated degredation of histones

Prevent transcription factors from binding to DNA

Prevent DNA degredation by endonucleases

Ubiquitin-mediated degradation of IkB, allowing NFkB to translocate to the nucleus and initiate transcription

Ubiquitin-mediated degradation of NFkB

Ubiquitin-mediated degradation of IkB, causing a conformational shift in NFkB that renders its DNA-binding domain inaccessible

Recruitment of transcription factors and coactivators of transcription to the cytoplasmically sequestered NFkB

Ubiquitin-mediated degradation of NFkB, allowing IkB to translocate to the nucleus and initiate transcription

Mediator is a coactivator of transcription and serves to recruit transcription factors and RNA polymerase II

Mediator suppresses transcription by methylating histone lysines

Mediator is not involved in gene expression

Mediator is a thermostable DNA polymerase that replicates DNA in extreme temperatures

Mediator facilitates alternative splicing of newly synthesized mRNA transcripts

Recruiting DNA polymerase

Recruiting RNA polymerase holoenzyme

Recruiting other transcription factors

Binding transcription factor-specific DNA motifs

Promoting euchromatin formation