Glycogenolysis Regulation - Biochemistry

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Question

Phosphorylation of glycogen phosphorylase has what effect on the enzyme?

Answer

Phosphorylation of glycogen phosphorylase activates it, converting it from its inactive B-form to its active A-form.

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Question

The process of glycogenolysis is an example of __________.

Answer

Phosphorolysis is the name given to the addition of phosphate across a bond. Remember that in glycogenolysis, glycogen phosphorylase adds a phosphate across the a-1,4-glycosidic bonds between the glucose units of glycogen. The result is that glucose leaves as glucose-1-phosphate. If hydrolysis were performed instead of phosphorolysis, free glucose would be severed from glycogen and would be able to leave the cell.

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Question

Which of the following statements about glycogen phosphorylase (GP) is incorrect?

Answer

AMP is an activator of GP, whereas ATP is an inhibitor of GP. GP cleaves the alpha 1-4 glycosidic bond between a terminal glucose molecule and the rest of the glycogen straight chain, yielding glucose-1-phosphate during glycogenolysis.

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