Gluconeogenesis occurs when an organism consumes abnormally high amounts of carbohydrates and fatty acids

Gluconeogenesis is primarily restricted to the liver and kidneys in mammalian species

Gluconeogenesis is a pathway for cells to create glucose from various precursors when glucose itself is unavailable

Gluconeogenesis will typically remain quiescent if the cell has an overabundance of energy from other pathways

Pyruvate and glycerol can be substrates for conversion to glucose in gluconeogenesis

Glucose

Acetyl-CoA

Citrate

Glycogen

Glucagon