Lipid Catabolism

Practice Questions

Biochemistry › Lipid Catabolism

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1

Before a fatty acid is able to undergo the beta-oxidation pathway, it must first be activated to form fatty acyl-CoA and transferred into the mitochondrial matrix from the cytoplasm of a cell via the activity of several enzymes.

What enzyme is responsible for synthesizing fatty acyl-CoA to be transported into the intermembrane space of a mitochondria?

2

Why does consuming alcohol (ethanol) promote storage of fatty acids in the form of triglycerides (fatty tissue), especially in the liver?

3

Which reaction in beta oxidation does hydroxyacyl-CoA dehydrogenase catalyze?

4

Why does consuming alcohol (ethanol) promote storage of fatty acids in the form of triglycerides (fatty tissue), especially in the liver?

5

Before a fatty acid is able to undergo the beta-oxidation pathway, it must first be activated to form fatty acyl-CoA and transferred into the mitochondrial matrix from the cytoplasm of a cell via the activity of several enzymes.

What enzyme is responsible for synthesizing fatty acyl-CoA to be transported into the intermembrane space of a mitochondria?

6

Which reaction in beta oxidation does hydroxyacyl-CoA dehydrogenase catalyze?

7

Which of the following statements is true about the role of apolipoprotein B (ApoB)100 in lipid metabolism?

I. ApoB 100 is synthesized by the liver.

II. ApoB 100 is a component of very low density, intermediate density and low density lipoproteins circulating in the blood.

III. ApoB 100 is a ligand for the LDL (low density lipoprotein) receptor in cells requiring intake of cholesterol.

IV. ApoB 100 is encoded by the same gene that produces ApoB 48.

8

Which of the following statements is true about the role of apolipoprotein B (ApoB)100 in lipid metabolism?

I. ApoB 100 is synthesized by the liver.

II. ApoB 100 is a component of very low density, intermediate density and low density lipoproteins circulating in the blood.

III. ApoB 100 is a ligand for the LDL (low density lipoprotein) receptor in cells requiring intake of cholesterol.

IV. ApoB 100 is encoded by the same gene that produces ApoB 48.

9

Fatty acyl-CoA enters the intermembrane space of a mitochondria via the enzyme acyl-CoA synthetase. Fatty acyl-CoA is the original input molecule of the beta-oxidation pathway, however, carnitine palmitoyl transferase I replaces the CoA with the molecule carnitine before being transported into the mitochondrial matrix.

Why does carnitine palmitoyl transferase replace coenzyme A with carnitine?

10

Fatty acyl-CoA enters the intermembrane space of a mitochondria via the enzyme acyl-CoA synthetase. Fatty acyl-CoA is the original input molecule of the beta-oxidation pathway, however, carnitine palmitoyl transferase I replaces the CoA with the molecule carnitine before being transported into the mitochondrial matrix.

Why does carnitine palmitoyl transferase replace coenzyme A with carnitine?

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