Lysine at position

Aspartate at position

Tryptophan at position

Asparagine at position

A substitution at any of these positions would render the enzyme inactive

Upon binding to the enzyme, the substrate changes the shape of the enzyme so that it fits perfectly

Upon binding to the enzyme, the substrate already fits perfectly into the active site

Upon binding to the enzyme, the substrate changes its own shape so that it fits perfectly

All of these are examples of induced fit

None of these are examples of induced fit